Approved Studies

Redefining severe asthma to high-risk asthma: Analysis of real-world data ot investigate patients who are at high risk of exacerbations, worsening of symptoms, and a loss of asthma control over time.

Cardiopulmonary risk model for patients with chronic obstructive pulmonary disease.

Real-world use of Breztri/Trixeo for the management of COPD in a UK primary care population.

Impact of biologic initiation on steroid burden and new-onset of potentially related OCS related risks in patients with severe asthma (SOLAR).

A retrospective observational study on effectiveness of influenza vaccine Supemtek compared to other vaccines in adults aged 18 years and above in the United Kingdom a feasibility study.

Determining the prevalence of severe asthma in children in UK primary care

Development and evaluation of clinical prediction models to estimate the risk of midgut
neuroendocrine tumours using statistical and machine learning approaches: an exploratory
study

Using Electronic Health Records (EHR) for the development of Personalised Hormonal Therapy

Characteristics, Treatment and Healthcare Resource Utilisation in Patients Diagnosed with Neuropathic or Chronic Pain Using Primary Care Electronic Health Records in the United Kingdom

AFLOAT: Predicting the risk of Advanced non-alcoholic Fatty Liver Disease in cOmmunity patients with Abnormal Transaminases

Drug utilisation and incident rates of adverse events in children with sialorrhoea who are treated with glycopyrronium

An exploratory study on epidemiological and genetic testing trends for retinitis pigmentosa and leber congenital amaurosis using primary care electronic records.

The incidence of psychological comorbidities in paediatric and young adults with inflammatory bowel disease, and the impacts of mental health conditions on quality of life, disease severity and resource utilisation: a population-based cohort study in the UK

Gallbladder pathology as an early sign of metachromatic leukodystrophy an exploratory study using electronic health records

A retrospective observational study on characteristics, treatment patterns, and healthcare resource use of patients with xerostomia in primary care settings using Optimum Patient Care Research Database in United Kingdom

Development of a predictive model algorithm to identify patients with hypophosphatasia, using Optimum Patient Care Record Database in United Kingdom

EffectIveness of bioloGics (by classes) in patieNts with dIfferent combination of T2 biomarkErs (IGNITE)

PhEnotypic Characteristics, coMorBidities and response to thErapeutic inteRventions associated with non-type 2 asthma (EMBER)

Clinical outcomes before and after biologic treatment by biologic class, by individual biologic, and by subgroups of baseline characteristics (LUMINANT)

A matched case control study to identify features associated with a group of rare diseases and examine the case identification accuracy of MendelScan, a rare disease case finding tool.

PRagmatic EVAluation of a quality Improvement programme for people living with modifiable high-risk COPD (PREVAIL)

ImPact of comoRbidity In Severe asthMa patients (PRISM)

Biologic usage patterns, clinical outcomes and healthcare utilization (CLEAR)

Exploring differences in asthma disease severity and pathways: variation by ethnicity and socioeconomic status

Deriving asthma subtypes from electronic health records using statistical learning

Patient characteristics, treatment patterns, clinical outcomes, and health care resource utilization in severe asthma subgroups: A retrospective analysis of the International Severe Asthma Registry

Unexplored associations with inflammatory skin conditions: a population-based cohort study of the risk of skin cancer, venous thromboembolism, and mental health conditions in atopic dermatitis and vitiligo

The prevalence of comorbidities in COPD patients, and their impact on health status and COPD symptoms in primary care patients: an UNLOCK study from the IPCRG

Patterns of Management of high-risk COPD in Primary Care, and Opportunities for optimising treatment in the United Kingdom 2000- 2019: Study Protocol

Expert opinion on the impact of inhaler choice on climate change and personalised healthcare

Data Resource Profile: Optimum Patient Care Research Database (OPCRD)

Impact of Covid-19 using Platform C19: Describing a cohort of real-life patients during the Covid-19 pandemic and assessing the impact of Covid-19 and related behaviour on chronic conditions, and the effect of chronic conditions on Covid-19 outcomes.

Development of a prediction model to identify Pompe disease and Fabry disease, based on UK primary care electronic health records

Defining and Characterising Responders To Biologic TrEAtment In Severe AsthMa Patients (BEAM)

An observational cohort study to describe intermittent OCS utilisation and its association with adverse outcomes and healthcare resource use and costs in asthma using the OPCRD and CPRD databases.

Impact of COVID-19 on asthma exacerbations: protocol for a cohort study in primary care

Comparative safety of extrafine beclometasone fixed dose combinations (FDC) and fluticasone FDC in COPD

The comparative effectiveness across severe asthma biologic classes (Anti-IL5 versus Anti-IgE) in patients eligible for both therapies

Asthma epidemiology, prevalence of asthma modifiable factors and healthcare utilisation due to asthma in England, Scotland, Wales, Northern Ireland and the UK

An observational evaluation of prescribing and safety of Glycopyrronium bromide for symptomatic treatment of severe sialorrhoea (drooling) in children with chronic neurological disorders

Impact of Initiating Biologics in Patients Receiving Long-term OCS or Frequent Rescue Steroids versus Those Not Receiving Biologics

Severe Asthma Super-Responders Delphi Exercise

External validation of a clinical prediction model for the diagnosis of asthma in primary care

Eosinophilic asthma phenotypes and associated clinical outcomes

A study on the Prescription Patterns of Short Acting Beta-2 Agonist (SABA) and its potential effects on asthma control: A Cross-Sectional Study on SABA use in Asthma

Longitudinal systemic corticosteroid utilization in the UK, 1990-2018 - An observational historical cohort study to describe the changes over time in drug utilization of systemic corticosteroids in 28 conditions in the OPCRD database.

IMP2ART Cluster Randomised Trial with a Nested Process Evaluation

Implications of ICS withdrawal in the real-life management of COPD

The Impact of Exacerbation Burden on Lung Function Trajectory in a Broad Asthma Population and Severe Asthma Population

Onset of asthma in severe asthma patients

Biologics in severe asthma: utilisation patterns, causes for discontinuation and switches

Biomarker Relatability in the International Severe Asthma Registry (BRISAR)

Development of a prognostic tool using machine learning for asthma exacerbations in adolescents and adults in a retrospective cohort in primary care

Evaluation of patient characteristics, care pathways, prescribing patterns and costs across cancer types.

A pragmatic, cluster randomized trial evaluating the impact of an enhanced adherence package (dual bronchodilator+add-on+app) on time to treatment failure and other clinical outcomes in exacerbating COPD patients with poor adherence to mono or dual therapy over one year

Effectiveness of Dymista in asthma patients with rhinitis

Effectiveness of Fostair (ICS/LABA) vs. dual bronchodilation (LABA/LAMA) in COPD (FELICITI Study)

Severe Asthma in Primary Care vs. ISAR Cohort

Treatment pathways, healthcare resource utilization and associated costs in patients with ulcerative colitis

Burden of cough in UK primary care

The Characterisation and Comparison of Eosinophilic and Non-eosinophilic Phenotypes of Severe Asthma

Validation of the new GOLD 2017 classification scheme among patients with Chronic Obstructive Pulmonary Disease

OPRI-1808: Dementia at Sea: a prevalence study in the United Kingdom

Demographic and Clinical Characteristics of Severe Asthma Patients Worldwide

An observational evaluation of the off-label prescribing and safety of glycopyrronium bromide (GLY) for symptomatic treatment of severe sialorrhoea (drooling) and/or hyperhidrosis (excessive sweating)

METNA RA Study

OPC Questionnaire Item Reduction: An exploratory study with the aim of reducing item numbers while the shorter version continues to be predictive of future exacerbations

British Lung Foundation (BLF) Asthma Management Project

Real-life Characterisation of Patients with Active Asthma and Type 2 Asthma Comorbidities

International Sever Asthma Registry (ISAR)

ASSIST: A clinical interventional study into Airways disease case-fInding and 'at risk' case management

Addition of antibiotics to usual care management of asthma exacerbations: a real-life comparative effectiveness study

Use of degarelix among patients with prostate cancer in daily practice